What are they?
These are laboratory-made relatives of psilocin, the active form of psilocybin. The Oregon State researchers call those found in their samples “syndelics” and say they don’t occur naturally in Psilocybe mushrooms (van Breemen et al., 2025).
Which have been found in gummies?
| Compound | Where it was found |
|---|---|
| 4-AcO-DET (4-acetoxy-N,N-diethyltryptamine) | Every TRE House product California listed (gummies, chocolate bars, syrup) (CDPH, 2025) |
| 4-AcO-DMT (4-acetoxy-N,N-dimethyltryptamine, sometimes called psilacetin) | Most TRE House products (CDPH, 2025). Six of eight gummies from Portland smoke and vape shops (Correia et al., 2025) |
| Mipracetin (4-AcO-MiPT) and 4-HO-DET | Two Portland gummies, one labelled only “mushroom blend extract” and one with no active ingredient listed (van Breemen et al., 2025) |
What is known about their safety?
Very little. The Oregon State authors say mipracetin and 4-HO-DET have unknown toxicology and pharmacology, which raises significant safety concerns (van Breemen et al., 2025). California’s health department called 4-AcO-DET and 4-AcO-DMT illegal psychedelics, described TRE House products as containing an analogue of psilocin (a Schedule I drug), and warned they could cause severe illness, hospitalisation or death (CDPH, 2025).
How would you know?
From the label, you wouldn’t. None of the products where these were found listed them. A home Ehrlich reagent test reacts to the indole family these compounds belong to, but can’t tell them apart from psilocin. See how to check a gummy.
Sources
- California Department of Public Health. CDPH Warns Consumers Not to Eat TRE House Brand Magic Mushroom Gummies, Chocolate Bars, and Syrup (NR25-024). December 11, 2025.
CDPH laboratory testing found 4-AcO-DET in all listed TRE House products and 4-AcO-DMT in most. Products were labelled with a 'Magic Mushroom Microdose Blend' and 'Proprietary Nootropic Mushroom Blend'. More than 1,000 lb of gummies were embargoed and destroyed. No illnesses had been reported at the time.
- Correia MS, Gonzaga MJ, Temple C, Gerona RR. Quantitative analysis of recreational psychoactive mushroom gummies in Portland, Oregon. Clin Toxicol (Phila). 2025;63(4):261-266.
Eight gummy products from seven Portland, Oregon smoke and vape shops, analysed by LC-QTOF-MS. Neither ibotenic acid nor muscimol was found in the two products claiming Amanita muscaria; seven of eight contained psilocin and six contained 4-AcO-DMT. One product labelled psilocybin-free tested positive for psilocybin; one 'nootropic' product contained undisclosed Δ9-THC; kavalactones were also detected.
- van Breemen RB, Simchuk D, Fritzsche B, Huson D, Kuzdzal SA, Ferguson J. Active Constituents of Psilocybin Mushroom Edibles. JAMA Netw Open. 2025;8(9):e2531345.
Tested 12 'magic mushroom' edibles (11 gummies, 1 chocolate) bought at retail shops in Portland, Oregon. None contained psilocybin. Eight contained active ingredients not disclosed on the label: psilocin (3), synthetic tryptamines mipracetin and 4-HO-DET (2), caffeine (1), kava extract (1) and cannabis extract including Δ9-THC (1). Four had no active ingredient detected. Muscimol and muscarine, listed on one label, were not detected in any product.