What is it?
Kratom comes from Mitragyna speciosa, a tree native to Southeast Asia (Karunakaran et al., 2026). Its best-known alkaloid, mitragynine, is an opioid agonist. CDC notes that repeated mitragynine use can increase the risk of opioid dependence (Michienzi et al., 2024).
7-hydroxymitragynine (7-OH) is a different matter. Traditional kratom leaf contains only trace amounts. Concentrated, semi-synthetic 7-OH products are sold in US shops, and 7-OH is a potent μ-opioid agonist with morphine-like pain-relieving effects, carrying a distinct risk profile from leaf kratom (Stogner, 2026).
Found in a mushroom gummy
A Virginia gummy sold as Wonderland Legal Psychedelics, labelled with Amanita muscaria, blue lotus and functional mushrooms, contained mitragynine along with psilocin, DMT and caffeine (Michienzi et al., 2024). Someone eating it would have had no way to know they were taking an opioid agonist.
Is it legal?
Regulation of 7-OH was changing in 2026. A 2026 review reports that in July 2026 the DEA announced its intent to temporarily place 7-OH in Schedule I (Stogner, 2026). We haven’t verified the final federal status. Check the DEA’s notices in the Federal Register before relying on any summary, including this one.
Sources
- Michienzi A, Hamlin J, Farah R, Bazydlo L. Notes from the Field: Schedule I Substances Identified in Nootropic Gummies Containing Amanita muscaria or Other Mushrooms - Charlottesville, Virginia, 2023-2024. MMWR Morb Mortal Wkly Rep. 2024;73(28):628-630.
Blue Ridge Poison Center (Virginia) managed five people evaluated after eating gummies labelled as containing Amanita muscaria (Sept 2023–June 2024), including a 3-year-old who was hospitalised. Investigators bought six packages of five brands from gas stations and smoke shops; four of six contained unlabelled psilocybin or psilocin, with caffeine, ephedrine, mitragynine (kratom) and DMT among other unlabelled findings.
- Stogner J. The Rise of Adulterated 7-Hydroxymitragynine Kratom Products Creates Challenges for Health Care and Policy. J Am Board Fam Med. 2026;39(1).
Describes the rise of concentrated, semi-synthetic 7-hydroxymitragynine (7-OH) products, a potent μ-opioid agonist, distinct from traditional kratom leaf, and notes DEA's July 2026 notice of intent to temporarily schedule 7-OH.
- Karunakaran T, Vicknasingam K, Chawarski MC. Kratom-labeled Products in the US Compared With Traditionally Consumed Natural Kratom in Southeast Asia. J Addict Med. 2026.
Contrasts kratom-labelled products sold in the US with traditional kratom in Southeast Asia, where a water decoction is made from freshly harvested leaves of the Mitragyna speciosa tree native to the region; the authors' preliminary evaluation did not detect 7-hydroxymitragynine in that decoction.